Vampire books are hot (or cold depending on how you look at it) and Zombie books and films are even hotter. What I am about to suggest has already been done numerous times, but for your next book, graphic novel, or autobiography, why not try a Vampire v. Zombie book? Consider the possiblities.
The battles of the undead. The Zombies are gory and stupid but able to walk at all times of the day, albeit slowly. The Vampires are intelligent and creepy, but limited to getting around at night. (I refuse to accept the Twilight version of vampires.) There are more Zombies than Vampires, giving the Zombies an unfair advantage. Besides their numbers, the Zombies would have an easier time killing the Vampires because they could use pieces of their coffins as stakes.